Fig. 1

The effects of differential expression of CatC on learning and memory ability. MWM test was performed in the untreated WT, CatCOE, and CatCKD mice. Place navigation test lasted for 5 days, and spatial probe test was performed on the sixth day. A Learning ability of untreated mice was determined by the swimming speed (a) and escape latency (b) of place navigation test. B Memory ability of untreated mice was determined by swimming speed (a) and escape latency (b) of spatial probe test. C LPS was injected after 5-day place navigation test as shown in time axis, and spatial probe test was performed after 24 h later. D Memory ability of LPS-injected mice was determined by swimming speed (a), escape latency (b), and crossing platform times (c) of spatial probe test. E Detection of learning ability of LPS-injected mice was illustrated in time axis. F Learning ability of 5-day place navigation test was determined by the swimming speed (a), escape latency (b); the escape latency of the sixth day is shown in c. The data represent mean ± SEM, n = 7–9. *P ≤ 0.05, ***P ≤ 0.001. *P ≤ 0.05, 2~5th days vs. 1st day in control, #P ≤ 0.05, WT + LPS vs. CatCOE + LPS in Fig. 1F (b)