Fig. 2From: Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathwayThe expression of CatC in the transgenic mouse brain before and after administration of LPS. WT, CatCOE, and CatCKD mice were intraperitoneally injected with LPS (100 μg/kg) for 24 h before the brains were isolated. Immunohistochemical staining for CatC was performed on the frozen brain sections. LPS induced CatC expression in WT (D) and CatCOE (E) mice, but not in CatCKD (F) mice. Scale bars, 100 μmBack to article page