Table 2 Between-group CSF inflammation marker comparisons
From: Glial activation and inflammation along the Alzheimer’s disease continuum
Variable | Groups | F(p) | ANOVA contrasts (p) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
1. Healthy controls (n = 36) | 2. Aβ + SCD (n = 18) | 3. Aβ + MCI (n = 40) | 4. AD dementia (n = 27) | 1 vs 2 | 1 vs 3 | 1 vs 4 | 2 vs 3 | 2 vs 4 | 3 vs 4 | ||
CSF sTREM2 | 3.1 (0.9) | 4.6 (1.9) | 4.0 (1.8) | 4.8 (1.7) | F = 7.0 (p < .001) | < .01b | < .05b | < .001b | n.s. b | n.s. b | < .05b |
CSF MCP-1 | 483 (124) | 510 (133) | 581 (160) | 645 (249) | F = 5.3 (p < .01) | n.s.b | < .05b | < .001b | n.s.b | < .05b | n.s.b |
CSF YKL-40 | 145 (46) | 188 (80) | 182 (69) | 221 (70) | F = 3.4 (p < .05) | n.s. b | n.s. b | < .01b | n.s. b | n.s. b | < .05b |
CSF fractalkine | 1823 (446) | 1924 (461) | 1790 (469) | 1983 (569) | F = 1.0 (p = n.s.) | a | a | a | a | a | a |
CSF clusterin | 2286 (828) | 2305 (719) | 2611 (817) | 2777 (769) | F = 2.6 (p = n.s.) | a | a | a | a | a | a |