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Table 2 Between-group CSF inflammation marker comparisons

From: Glial activation and inflammation along the Alzheimer’s disease continuum

Variable Groups F(p) ANOVA contrasts (p)
1. Healthy controls (n = 36) 2. Aβ + SCD (n = 18) 3. Aβ + MCI (n = 40) 4. AD dementia (n = 27) 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 3 vs 4
CSF sTREM2 3.1 (0.9) 4.6 (1.9) 4.0 (1.8) 4.8 (1.7) F = 7.0 (p < .001) < .01b < .05b < .001b n.s. b n.s. b < .05b
CSF MCP-1 483 (124) 510 (133) 581 (160) 645 (249) F = 5.3 (p < .01) n.s.b < .05b < .001b n.s.b < .05b n.s.b
CSF YKL-40 145 (46) 188 (80) 182 (69) 221 (70) F = 3.4 (p < .05) n.s. b n.s. b < .01b n.s. b n.s. b < .05b
CSF fractalkine 1823 (446) 1924 (461) 1790 (469) 1983 (569) F = 1.0 (p = n.s.) a a a a a a
CSF clusterin 2286 (828) 2305 (719) 2611 (817) 2777 (769) F = 2.6 (p = n.s.) a a a a a a
  1. Abbreviations: n.s. non-significant (p > .05), Aβ+ indicates CSF Aβ42 below the normal range
  2. aContrasts not performed due to non-significant ANOVA
  3. bEqual distribution assumed