Fig. 6
From: The spleen may be an important target of stem cell therapy for stroke
Therapeutic stem cells after stroke migrate to peripheral organs, such as the spleen. a After stroke, the patient was treated by intravenous injection of stem cells. b, c Stem cells in circulation are stimulated by IL-1β, IL-6 and TNF-α after stroke, and their chemokine ligand levels are elevated, thus enhancing the capability of stem cells to recruit inflammatory cells [194, 195]. d Through migration and adhesion, stem cells migrate rapidly to PIOs, such as the spleen, to play a regulatory role