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Table 3 Biomarker concentrations in athletes with SRC and healthy athletes in the subacute period

From: Evidence of a distinct peripheral inflammatory profile in sport-related concussion

Biomarker Healthy male (n = 43) SRC male (n = 21) Healthy female (n = 44) SRC female (n = 22) P value FDR
IFN-γ 3.5 (2.8–5.2) 3.4 (2.6–5.5) 3.9 (2.9–7.8) 3.7 (2.6–4.8) 0.32 No
TNF-α 1.7 (1.4–2.0) 1.7 (1.4–2.1) 1.5 (1.3–2.0) 1.5 (1.2–1.9) 0.83 No
MPO (ng/mL) 11.2 (8.1–15.8) 12.3 (7.7–20.2) 7.9 (5.8–11.1) 9.0 (7.5–12.2) 0.63 No
IL-8 1.9 (1.6–2.5) 2.0 (1.7–2.4) 1.6 (1.1–2.2) 1.8 (1.0–2.3) 0.69 No
Eotaxin 85.5 (75.1–106.6) 95.4 (83.4–126.7) 73.3 (63.3–89.3) 81.0 (64.5–93.4) 0.07 No
IP-10 159.2 (129.1–226.5) 181.5 (136.1–220.1) 156.1 (132.5–251.2) 207.7 (165.3–288.9) 0.13 No
MCP-1 68.9 (58.8–77.7) 66.9 (57.7–75.6) 58.7 (50.9–69.0) 53.3 (44.2–63.7) 0.25 No
MCP-4 20.8 (16.3–25.5) 26.5 (20.5–32.1) 19.0 (16.8–22.4) 21.2 (18.5–27.7) 0.00 Yes
MIP-1β 29.2 (25.9–40.3) 42.1 (31.4–53.6) 27.7 (22.2–33.6) 31.8 (26.0–39.4) 0.00 Yes
TARC 50.0 (38.9–75.2) 71.3 (44.8–94.6) 42.7 (32.7–54.6) 54.0 (37.5–67.5) 0.02 No
  1. SRC sport-related concussion; FDR false discovery rate; IFN-γ interferon-γ; TNF-α tumor necrosis factor-α; MPO myeloperoxidase; IL-8 interleukin-8; IP-10 interferon gamma-induced protein-10; MCP-1, MCP-4 monocyte chemoattractant protein-1, -4; MIP-1α, MIP-1β macrophage inflammatory protein-1α, -1β; TARC thymus and activation-regulated chemokine
  2. All values reported as the median and interquartile range, in picograms per milliliter unless otherwise stated
  3. P values are derived from bootstrap ratios, controlled for sex, corrected at FDR = 0.05