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Table 4 Biomarker concentrations in athletes with MSK injury and healthy athletes in the subacute period

From: Evidence of a distinct peripheral inflammatory profile in sport-related concussion

Biomarker

Healthy male (n = 50)

MSK male (n = 17)

Healthy female (n = 45)

MSK female (n = 13)

P value

FDR

IFN-γ

3.5 (2.4–4.5)

3.7 (3.2–5.1)

3.9 (2.8–6.6)

4.3 (3.2–9.9)

0.29

No

TNF-α

1.7 (1.4–2.0)

1.9 (1.7–2.2)

1.6 (1.3–2.1)

1.6 (1.2–1.8)

0.36

No

MPO (ng/mL)

10.8 (7.9–16.2)

9.4 (7.9–13.4)

7.2 (5.8–11.0)

8.6 (7.3–10.5)

0.95

No

IL-8

1.9 (1.6–2.5)

2.8 (1.8–3.2)

1.6 (1.2–2.2)

1.9 (1.6–2.2)

0.13

No

Eotaxin

84.2 (73.6–99.3)

98.1 (86.9–117.9)

73.6 (63.8–95.8)

78.0 (57.4–90.2)

0.28

No

IP-10

178.8 (130.2–235.4)

219.3 (153.4–246.6)

155.5 (132.3–246.6)

182.2 (139.1–287.3)

0.10

No

MCP-1

68.8 (60.2–77.4)

72.5 (60.7–80.0)

59.1 (48.8–70.2)

57.5 (49.8–62.1)

0.83

No

MCP-4

21.5 (17.9–25.6)

27.5 (20.6–31.9)

19.0 (16.8–22.4)

22.1 (17.8–27.8)

0.03

No

MIP-1β

35.6 (26.8–42.7)

28.2 (22.7–45.6)

28.2 (23.2–33.6)

31.0 (26.2–34.9)

0.84

No

TARC

49.2 (38.4–75.6)

73.9 (43.2–82.3)

42.9 (33.0–58.1)

58.1 (46.4–70.2)

0.00

Yes

  1. MSK musculoskeletal; FDR false discovery rate; IFN-γ interferon-γ; TNF-α tumor necrosis factor-α; MPO myeloperoxidase; IL-8 interleukin-8; IP-10 interferon gamma-induced protein-10; MCP-1, MCP-4 monocyte chemoattractant protein-1, -4; MIP-1α, MIP-1β macrophage inflammatory protein-1α, -1β; TARC thymus and activation-regulated chemokine
  2. All values reported as the median and interquartile range, in picograms per milliliter unless otherwise stated
  3. P values are derived from bootstrap ratios, controlled for sex, corrected at FDR = 0.05