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Table 4 Biomarker concentrations in athletes with MSK injury and healthy athletes in the subacute period

From: Evidence of a distinct peripheral inflammatory profile in sport-related concussion

Biomarker Healthy male (n = 50) MSK male (n = 17) Healthy female (n = 45) MSK female (n = 13) P value FDR
IFN-γ 3.5 (2.4–4.5) 3.7 (3.2–5.1) 3.9 (2.8–6.6) 4.3 (3.2–9.9) 0.29 No
TNF-α 1.7 (1.4–2.0) 1.9 (1.7–2.2) 1.6 (1.3–2.1) 1.6 (1.2–1.8) 0.36 No
MPO (ng/mL) 10.8 (7.9–16.2) 9.4 (7.9–13.4) 7.2 (5.8–11.0) 8.6 (7.3–10.5) 0.95 No
IL-8 1.9 (1.6–2.5) 2.8 (1.8–3.2) 1.6 (1.2–2.2) 1.9 (1.6–2.2) 0.13 No
Eotaxin 84.2 (73.6–99.3) 98.1 (86.9–117.9) 73.6 (63.8–95.8) 78.0 (57.4–90.2) 0.28 No
IP-10 178.8 (130.2–235.4) 219.3 (153.4–246.6) 155.5 (132.3–246.6) 182.2 (139.1–287.3) 0.10 No
MCP-1 68.8 (60.2–77.4) 72.5 (60.7–80.0) 59.1 (48.8–70.2) 57.5 (49.8–62.1) 0.83 No
MCP-4 21.5 (17.9–25.6) 27.5 (20.6–31.9) 19.0 (16.8–22.4) 22.1 (17.8–27.8) 0.03 No
MIP-1β 35.6 (26.8–42.7) 28.2 (22.7–45.6) 28.2 (23.2–33.6) 31.0 (26.2–34.9) 0.84 No
TARC 49.2 (38.4–75.6) 73.9 (43.2–82.3) 42.9 (33.0–58.1) 58.1 (46.4–70.2) 0.00 Yes
  1. MSK musculoskeletal; FDR false discovery rate; IFN-γ interferon-γ; TNF-α tumor necrosis factor-α; MPO myeloperoxidase; IL-8 interleukin-8; IP-10 interferon gamma-induced protein-10; MCP-1, MCP-4 monocyte chemoattractant protein-1, -4; MIP-1α, MIP-1β macrophage inflammatory protein-1α, -1β; TARC thymus and activation-regulated chemokine
  2. All values reported as the median and interquartile range, in picograms per milliliter unless otherwise stated
  3. P values are derived from bootstrap ratios, controlled for sex, corrected at FDR = 0.05