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Table 5 Biomarker concentrations in athletes with MSK injury and healthy athletes at medical clearance

From: Evidence of a distinct peripheral inflammatory profile in sport-related concussion

Biomarker Healthy male (n = 43) SRC male (n = 14) Healthy female (n = 44) SRC female (n = 18) P value FDR
IFN-γ 3.5 (2.8–5.2) 2.9 (2.5–4.3) 3.9 (2.9–7.8) 2.9 (2.3–4.2) 0.02 No
TNF-α 1.7 (1.4–2.0) 1.5 (1.2–1.8) 1.5 (1.3–2.0) 1.6 (1.2–2.1) 0.48 No
MPO (ng/mL) 11.2 (8.1–15.8) 9.0 (5.7–15.2) 7.9 (5.8–11.1) 7.6 (6.0–12.4) 0.34 No
IL-8 1.9 (1.6–2.5) 2.4 (1.5–2.7) 1.6 (1.1–2.2) 1.6 (1.2–1.9) 0.92 No
Eotaxin 85.5 (75.1–106.6) 91.5 (77.4–99.5) 73.3 (63.3–89.3) 87.7 (71.2–95.7) 0.12 No
IP-10 159.2 (129.1–226.5) 177.7 (140.0–201.0) 156.1 (132.5–251.2) 187.2 (145.6–233.3) 0.38 No
MCP-1 68.9 (58.8–77.7) 70.1 (61.0–84.0) 58.7 (50.9–69.0) 57.5 (54.4–78.5) 0.48 No
MCP-4 20.8 (16.3–25.5) 25.2 (23.4–27.1) 19.0 (16.8–22.4) 20.0 (17.8–36.0) 0.00 No
MIP-1β 29.2 (25.9–40.3) 41.3 (36.5–45.0) 27.7 (22.2–33.6) 32.0 (25.0–40.9) 0.01 No
TARC 50.0 (38.9–75.2) 54.3 (45.6–67.3) 42.7 (32.7–54.6) 46.9 (39.1–56.3) 0.24 No
  1. SRC sport-related concussion; FDR false discovery rate; IFN-γ interferon-γ; TNF-α tumor necrosis factor-α; MPO myeloperoxidase; IL-8interleukin-8; IP-10 interferon gamma-induced protein-10; MCP-1, MCP-4 monocyte chemoattractant protein-1, -4; MIP-1α, MIP-1β macrophage inflammatory protein-1α, -1β; TARC thymus and activation-regulated chemokine
  2. All values reported as the median and interquartile range, in picograms per milliliter unless otherwise stated
  3. P values are derived from bootstrap ratios, controlled for sex, corrected at FDR = 0.05