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Table 6 Biomarker concentrations in athletes with MSK injury and healthy athletes at medical clearance

From: Evidence of a distinct peripheral inflammatory profile in sport-related concussion

Biomarker Healthy male (n = 50) MSK male (n = 12) Healthy female (n = 45) MSK female (n = 6) P value FDR
IFN-γ 3.5 (2.4–4.5) 4.2 (3.6–4.5) 3.9 (2.8–6.6) 3.4 (3.0–4.6) 0.09 No
TNF-α 1.7 (1.4–2.0) 2.1 (1.8–2.2) 1.6 (1.3–2.1) 1.4 (1.2–1.7) 0.14 No
MPO (ng/mL) 10.8 (7.9–16.2) 8.8 (7.2–12.5) 7.2 (5.8–11.0) 9.6 (9.2–14.7) 0.99 No
IL-8 1.9 (1.6–2.5) 2.3 (1.7–3.4) 1.6 (1.2–2.2) 2.4 (1.8–2.7) 0.01 No
Eotaxin 84.2 (73.6–99.3) 92.3 (84.9–107.9) 73.6 (63.8–95.8) 83.4 (70.8–95.0) 0.02 No
IP-10 178.8 (130.2–235.4) 185.4 (151.4–275.9) 155.5 (132.3–246.6) 136.8 (115.9–167.3) 0.85 No
MCP-1 68.8 (60.2–77.4) 65.8 (52.4–85.5) 59.1 (48.8–70.2) 57.3 (49.4–64.5) 0.68 No
MCP-4 21.5 (17.9–25.6) 21.6 (18.6–22.7) 19.0 (16.8–22.4) 28.5 (21.1–30.5) 0.26 No
MIP-1β 35.6 (26.8–42.7) 26.8 (24.5–37.9) 28.2 (23.2–33.6) 26.1 (24.2–37.1) 0.33 No
TARC 49.2 (38.4–75.6) 55.6 (38.7–77.2) 42.9 (33.0–58.1) 88.6 (54.7–112.8) 0.07 No
  1. MSK musculoskeletal; FDR false discovery rate; IFN-γ interferon-γ; TNF-α tumor necrosis factor-α; MPO myeloperoxidase; IL-8 interleukin-8; IP-10 interferon gamma-induced protein-10; MCP-1, MCP-4 monocyte chemoattractant protein-1, -4; MIP-1α, MIP-1β macrophage inflammatory protein; TARC thymus and activation-regulated chemokine
  2. All values reported as the median and interquartile range, in picograms per milliliter unless otherwise stated
  3. P values are derived from bootstrap ratios, controlled for sex, corrected at FDR = 0.05