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Table 6 Biomarker concentrations in athletes with MSK injury and healthy athletes at medical clearance

From: Evidence of a distinct peripheral inflammatory profile in sport-related concussion

Biomarker

Healthy male (n = 50)

MSK male (n = 12)

Healthy female (n = 45)

MSK female (n = 6)

P value

FDR

IFN-γ

3.5 (2.4–4.5)

4.2 (3.6–4.5)

3.9 (2.8–6.6)

3.4 (3.0–4.6)

0.09

No

TNF-α

1.7 (1.4–2.0)

2.1 (1.8–2.2)

1.6 (1.3–2.1)

1.4 (1.2–1.7)

0.14

No

MPO (ng/mL)

10.8 (7.9–16.2)

8.8 (7.2–12.5)

7.2 (5.8–11.0)

9.6 (9.2–14.7)

0.99

No

IL-8

1.9 (1.6–2.5)

2.3 (1.7–3.4)

1.6 (1.2–2.2)

2.4 (1.8–2.7)

0.01

No

Eotaxin

84.2 (73.6–99.3)

92.3 (84.9–107.9)

73.6 (63.8–95.8)

83.4 (70.8–95.0)

0.02

No

IP-10

178.8 (130.2–235.4)

185.4 (151.4–275.9)

155.5 (132.3–246.6)

136.8 (115.9–167.3)

0.85

No

MCP-1

68.8 (60.2–77.4)

65.8 (52.4–85.5)

59.1 (48.8–70.2)

57.3 (49.4–64.5)

0.68

No

MCP-4

21.5 (17.9–25.6)

21.6 (18.6–22.7)

19.0 (16.8–22.4)

28.5 (21.1–30.5)

0.26

No

MIP-1β

35.6 (26.8–42.7)

26.8 (24.5–37.9)

28.2 (23.2–33.6)

26.1 (24.2–37.1)

0.33

No

TARC

49.2 (38.4–75.6)

55.6 (38.7–77.2)

42.9 (33.0–58.1)

88.6 (54.7–112.8)

0.07

No

  1. MSK musculoskeletal; FDR false discovery rate; IFN-γ interferon-γ; TNF-α tumor necrosis factor-α; MPO myeloperoxidase; IL-8 interleukin-8; IP-10 interferon gamma-induced protein-10; MCP-1, MCP-4 monocyte chemoattractant protein-1, -4; MIP-1α, MIP-1β macrophage inflammatory protein; TARC thymus and activation-regulated chemokine
  2. All values reported as the median and interquartile range, in picograms per milliliter unless otherwise stated
  3. P values are derived from bootstrap ratios, controlled for sex, corrected at FDR = 0.05