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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

Fig. 1

The neuroprotective effects of Apelin 13. a Apelin 13 was given intracerebroventricularly 15 min before reperfusion and followed by once daily for 3 days after stroke. TTC staining was performed to evaluate the infarct formation after stroke. b Neurological scores in the rats after stroke. c Apelin 13 reduced cerebral edema. The water content of ipsilateral hemispheres was measured to evaluate the degree of cerebral edema. d Bax, Bcl-2, cleaved caspase 3, and cleaved caspase 9 were detected by western blot as mentioned in the “Methods” section. Levels of S-100β (e) and NSE (f) in serum were detected by relative kits. ##P < 0.01 vs. the sham group; *P < 0.05, **P < 0.01 vs. the model group

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