Fig. 5

Genetic ablation of TRPC6 in 129S-C57BL/6-F2 mice prevents TBI-associated aortic endothelial dysfunction. a Summary data for the active tensions measured in the presence of 70 mM KCl in aortic arch rings from sham or TBI TRPC6 knockout mice. b Concentration-response relationships for phenylephrine-induced contractions in aortic arch rings from sham and TBI TRPC6 knockout mice. c Concentration-response relationships for acetylcholine-induced contractions in phenylephrine-precontracted rings from sham and TBI TRPC6 knockout mice. The insets in b and c show the sample traces of active tension changes in aortas from sham (black lines) and TBI (red lines) mice. PE - phenylephrine, ACh - acetylcholine