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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction

Fig. 8

TLR4 inhibitor, TAK-242, treatment decreased TBI-associated aortic endothelial dysfunction in C57BL/6 mice. a Summary data for the active tensions measured in the presence of 70 mM KCl in aortic arch rings from TBI C57BL/6 mice treated in vivo with DMSO or TAK-242 via intraperitoneal injection for 7 days. b Concentration-response relationships for phenylephrine-induced contractions in aortic arch rings from TBI C57BL/6 mice treated with DMSO or TAK-242 in vivo. c Concentration-response relationships for acetylcholine-induced contractions in phenylephrine-precontracted rings from sham and TBI C57BL/6 mice treated with DMSO or TAK-242 in vivo. The insets in b and c show the sample traces of active tension changes in aortas from the TBI-DMSO group (black lines) and TBI-TAK-242 group (red lines) mice. PE - phenylephrine, ACh - acetylcholine

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