Fig. 1

Cytokine levels in maternal plasma as measured by Luminex multiplex panel or ELISA (CCL5 only). All detectable cytokines/chemokines were elevated in the plasma of mothers that received polyI:C compared to those that received saline. Plasma IL-2, IL-10, IL-12, TNF-α and CXCL1 were significantly more elevated in Map2k7 Hz mice than they were in WT mice, following polyI:C administration compared to saline. Results shown are mean ± SEM, N = 4/group. Data were analysed by two-way ANOVA with maternal genotype (WT or Map2k7 Hz) and treatment (saline or polyI:C) as factors. F values are provided in Additional file 1. *p < 0.05, **p < 0.01, ***p < 0.001 (main effect—ANOVA). ^#p < 0.05 vs WT, the same treatment (post-hoc Fisher’s test)