Table 1 Mating combinations. Four pairs in each group were successfully time mated, totalling 16 pairs. Each pair produces WT and Map2k7 Hz embryos
Breeding | Treatment | Maternal plasma samples | Litters | Independent WT embryonic brain samples | Independent Hz embryonic brain samples |
|---|---|---|---|---|---|
Female WT × Male Map2k7 Hz | Saline (vehicle) | 4 × WT | 4 | 4 | 4 |
Female WT × Male Map2k7 Hz | PolyI:C (20 mg/kg sc.) | 4 × WT | 4 | 4 | 4 |
Female Map2k7 Hz × Male WT | Saline (vehicle) | 4 × Hz | 4 | 4 | 4 |
Female Map2k7 Hz × Male WT | PolyI:C (20 mg/kg sc.) | 4 × Hz | 4 | 4 | 4 |