Fig. 4From: AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expressionSubcutaneous injection of IL-1ra attenuates CFA-induced inflammatory pain of mice. a Effects of a single injection of IL-1ra (0.5, 5, or 7.5 μg/20 μl) on mechanical allodynia induced by CFA in mice. b Effects of a single injection of IL-1ra (0.5, 5, or 7.5 μg/20 μl) on thermal hyperalgesia induced by CFA in mice. Data are expressed as mean ± SEM, n = 8 mice/group. Two-way ANOVA revealed a significant difference at *P < 0.05 vs. Control group and #P < 0.05 vs. CFA + VEH (vehicle of IL-1ra, sterilized PBS) group. AI, AICARBack to article page