Fig. 1
Ac2-26 decreases loss of hippocampal neurons in the SE model. a, c, e Representative photomicrographs of FJC staining show degenerating neurons (white arrows) in the anterior and posterior hippocampal CA1 and CA3 regions 24 h after of SE-onset. Few FJC+ cells (white arrows) were detected in the SE+Ac2-26 group. No FJC signal was observed in the hippocampus of control rats (Naive and Sham). b, d, f Healthy neurons (black arrows) and picnotic cells (black arrowheads), the latter were more evident in the SE group. Insets, details of degenerated and healthy neurons from squared areas. Stain, Fluoro Jade-C (a, c, e) and haematoxilin-eosin (b, d, f). Bars, 200 μm; 40 μm (insets)