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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE

Fig. 1

PERK activation specifically in oligodendrocyte attenuated neuron loss in the CNS of EAE mice. ac NeuN IHC showed that the number of lower motor neurons was significantly increased in the lumbar spinal cord (SC) of AP20187-treated PLP/Fv2E-PERK mice at PID 21 compared to vehicle-treated mice. df NeuN IHC showed that the number of neurons was significantly increased in the layer V of the primary motor cortex of AP20187-treated PLP/Fv2E-PERK mice at PID 21 compared to vehicle-treated mice. gi. Calbindin 2 IHC showed that the number of Purkinje neurons was significantly increased in the cerebellum of AP20187-treated PLP/Fv2E-PERK mice at PID 21 compared to vehicle-treated mice. Scale bars: a, b, d, e, g, h, 50 μm. N = 5 animals. Error bars represent SD, *P < 0.05, **P < 0.01, ***P < 0.0001

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