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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE

Fig. 3

ATF4 inactivation specifically in oligodendrocytes had no effect on axons and neurons in the CNS under normal conditions. ac SMI 31 IHC revealed that there was a comparable number of total axons in the lumbar spinal cord of 10-week-old ATF4 cKO mice and control mice. df NeuN IHC showed that ATF4 inactivation specifically in oligodendrocytes did not significantly change the number of lower motor neurons in the lumbar spinal cord of 10-week-old mice. gi NeuN IHC showed that ATF4 inactivation in oligodendrocytes did not significantly change the number of neurons in the layer V of the primary motor cortex in 10-week-old mice. jl Calbindin 2 IHC showed that there was a comparable number of Purkinje neurons in the cerebellum of 10-week-old ATF4 cKO mice and control mice. Scale bars: a, b, 20 μm; d, e, g, h, j, k, 50 μm. N = 4 animals. Error bars represent SD. n.s. not significant

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