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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE

Fig. 6

ATF4 inactivation specifically in oligodendrocytes did not change the infiltration of inflammatory cells in the CNS white matter during EAE. ac CD3 immunostaining showed that ATF4 inactivation specifically in oligodendrocytes did not significantly change the number of CD3-positive T cells in the white matter of the lumbar spinal cord in EAE mice at PID21. Red fluorescence: CD3, blue fluorescence: DAPI. Arrows pointed out representative CD3-positive T cells. df CD11b immunostaining showed that ATF4 inactivation specifically in oligodendrocytes did not significantly change the number of CD11b positive microglia/macrophages in the white matter of the lumbar spinal cord in EAE mice at PID21. Red fluorescence: CD11b, blue fluorescence: DAPI. Arrows pointed out representative CD11b-positive microglia/macrophages. Scale bars: a, b, d, e, 100 μm. N = 4 animals. Error bars represent SD, n.s. not significant

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