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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

Fig. 3

Cognitive evaluation by NOR test. Rats (n = 8 per group) exposed to the training with two identical objects did not show any statistical variation in the RI% (F(4,35) 0.6122; p = 0.6566) among the experimental groups (a). Twenty-four hours after the training was the evaluation of rats’ preference toward novel object. The results of one-way ANOVA showed b a significant effect of treatment (F(4,35) = 5.971; p < 0.001). The post hoc analysis conducted by Tukey’s multiple comparison test showed a significant reduction of RI% in the Aβ1-42 group with respect to control (p < 0.01), Aβ1-42 + IFNβ1a (p < 0.01), and IFNβ1a (p < 0.05) groups (b). In the Aβ1-42 + IFNβ1a group, the treatment with IFNβ1a full counteracted the RI% reduction observed in the Aβ1-42 group. In the IFNβ1a and sham groups, the RI% did not change as compared to control. *P < 0.05, **P < 0.01

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