Fig. 6
IFNβ1a effects on astroglial cell activation by Aβ1-42. a GFAP immunohistochemistry in the hippocampus. b Count of GFAP positive cells and c quantitative Western blot analyses of GFAP protein levels. b Count of astrocytes number showed no significant changes in all experimental groups. c By contrast, the quantitative Western blot analyses of GFAP protein levels revealed that in the Aβ1-42 group (n = 6), GFAP protein levels were significantly increased and this increase was not counteracted by treatment with IFNβ1a (n = 6) in the Aβ1-42 + IFNβ1a group (n = 6). Note IFNβ1a alone significantly reduced the GFAP protein levels as compared to the control group. Scale: 100 μm *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001