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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT

Fig. 3

TNF-α mediated the upregulation of p-STAT3 following L5-VRT. a The upregulation of p-STAT3 was induced by L5-VRT. n = 5 per group, **P < 0.01 versus the sham group. b Representative blots and histogram showed the effect of thalidomide on the p-STAT3 upregulation in the rats with L5-VRT. n = 5 per group, **P < 0.01 versus the sham group, ##P < 0.01 versus the corresponding L5-VRT group. c The immunofluorescence staining showed the colocalization of TNF-α with p-STAT3. n = 3 per group, Scale bar, 50 μm

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