Therapeutic hypercapnia reduces blood–brain barrier damage possibly via protein kinase Cε in rats with lateral fluid percussion injury

Yang, Wan-Chao; Wang, Qi; Chi, Lai-Ting; Wang, Yue-Zhen; Cao, Hong-Ling; Li, Wen-Zhi

doi:10.1186/s12974-019-1427-2

Journal of Neuroinflammation

Table 1 Physiologic parameters

From: Therapeutic hypercapnia reduces blood–brain barrier damage possibly via protein kinase Cε in rats with lateral fluid percussion injury

	Group	Time
		Baseline	Trauma	CO₂ inhalation
		Baseline	Trauma	15 min	30 min	60 min	90 min	120 min	150 min	180 min
ICP (mmHg)	Sham	14.50 ± 0.46	14.25 ± 0.34	15.75 ± 0.60	15.00 ± 0.29	15.25 ± 0.45	14.50 ± 0.46	14.75 ± 0.34	14.50 ± 0.46	14.50 ± 0.20
	T	14.75 ± 0.53	68.00 ± 0.76^#	17.25 ± 0.53	17.00 ± 1.26	17.25 ± 0.93	18.25 ± 1.36^#	19.50 ± 1.93^#	18.75 ± 1.17^#	19.25 ± 0.97^#
	T+H	13.50 ± 0.61	67.00 ± 0.65^#	21.25 ± 0.60*^#	18.50 ± 1.06^#	16.00 ± 1.61	14.50 ± 0.94*	14.50 ± 1.10*	15.50 ± 1.02*	15.00 ± 0.76*
MAP (mmHg)	Sham	106.89 ± 2.81	106.89 ± 2.76	104.09 ± 3.32	104.78 ± 3.61	106.33 ± 2.29	106.50 ± 1.76	110.61 ± 2.30	105.72 ± 3.29	106.48 ± 4.48
	T	99.56 ± 3.57	163.76 ± 5.15^#	90.61 ± 3.18^#	91.22 ± 4.0^#	94.83 ± 2.05^#	97.00 ± 1.96	102.39 ± 4.72	99.89 ± 5.92	97.06 ± 5.06
	T+H	102.89 ± 2.51	163.38 ± 5.22^#	87.22 ± 3.74^#	89.33 ± 2.12^#	97.83 ± 4.08	100.28 ± 3.37	100.42 ± 3.49	101.94 ± 2.66	100.74 ± 2.64
PaO₂ (mmHg)	Sham	103.42 ± 2.6		110.75 ± 2.42	113.22 ± 2.20	114.5 ± 2.42	112.62 ± 2.78	112.82 ± 1.64	113.85 ± 2.12	113.67 ± 2.11
	T	108.87 ± 3.69		104.58 ± 5.00	111.78 ± 4.16	110.72 ± 3.55	109.10 ± 5.0	111.37 ± 2.93	109.38 ± 2.44	108.55 ± 3.68
	T+H	104.83 ± 3.32		118.82 ± 5.23*	130.28 ± 3.08*^#	138.78 ± 4.10*^#	138.30 ± 6.28*^#	141.40 ± 7.00*^#	138.65 ± 3.36*^#	146.87 ± 3.65*^#
PaCO₂ (mmHg)	Sham	37.10 ± 1.18		39.97 ± 1.67	38.38 ± 1.52	37.20 ± 0.73	39.07 ± 1.07	39.58 ± 1.47	42.45 ± 1.51	39.93 ± 1.31
	T	37.33 ± 2.01		41.90 ± 2.85	39.83 ± 2.06	39.93 ± 1.72	40.67 ± 2.97	37.92 ± 2.44	38.48 ± 2.73	39.20 ± 2.47
	T+H	34.05 ± 1.83		72.53 ± 8.15*^#	84.25 ± 4.21*^#	89.97 ± 4.07*^#	97.78 ± 2.29*^#	94.60 ± 4.43*^#	92.48 ± 3.98*^#	91.58 ± 3.56*^#
pH	Sham	7.38 ± 0.02		7.38 ± 0.02	7.40 ± 0.01	7.39 ± 0.02	7.38 ± 0.01	7.43 ± 0.01	7.40 ± 0.02	7.38 ± 0.01
	T	7.41 ± 0.02		7.36 ± 0.01	7.37 ± 0.02	7.39 ± 0.02	7.35 ± 0.02	7.34 ± 0.02	7.33 ± 0.02	7.37 ± 0.02
	T+H	7.39 ± 0.01		7.15 ± 0.01*^#	7.06 ± 0.04*^#	7.07 ± 0.02*^#	7.05 ± 0.02*^#	7.06 ± 0.01*^#	7.08 ± 0.02*^#	7.09 ± 0.02*^#

ICP, MAP, PaO₂, PaCO₂ and pH in the sham group, group T, and group T+H. Data were expressed as means ± SEM. n = 6
^#p < 0.05 vs. sham, *p < 0.05 vs. group T

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