Fig. 1

Effects of LPS injections on body weight, food intake, and water intake. The first injection of vehicle or LPS was given on day 0 and the second on days 2 (a) or 4 (b). Vehicle-2 (4) days-vehicle, mice were injected intraperitoneally with saline for the first and second injections; LPS-2 (4) days-vehicle, mice were injected intraperitoneally with LPS for the first injection and saline for the second injection; LPS-2 (4) days-LPS, mice were injected intraperitoneally with LPS for the first and second injections. N = 5. **P < 0.01, ***P < 0.001 LPS-2 (4) days-LPS vs vehicle-2 (4) days-vehicle, ^##P < 0.01, ^###P < 0.001 LPS-2 (4) days-LPS vs LPS-2 (4) days-vehicle, ⁺⁺⁺P < 0.001 LPS-2 (4) days-vehicle vs vehicle-2 (4) days-vehicle, determined by one-way ANOVA with Scheffé’s post hoc test