Fig. 9

Overlap between differentially expressed genes in peripheral blood (current study) and perihematomal brain tissue [15] between patients with ICH and controls. There was significant enrichment (p = 6.4 × 10⁻⁰⁸) of neutrophil-specific genes in the overlap of 46 genes. The underlined genes are neutrophil-specific (based on the HeamAtlas [24]). * SATB1 (SATB Homeobox 1)—T cell-specific based on [25]. ** UBE2J1 (ubiquitin conjugating enzyme E2 J1)—B lymphocyte-specific based on [24]. *** UPP1 (uridine phosphorylase 1)—Monocyte-specific based on [24]. The green yellow genes ALOX5 (arachidonate 5-lipoxygenase) and PYGL (glycogen phosphorylase L) are hub genes in the greenyellow ICH module. The red gene AAK1 (AP2 Associated Kinase) is a hub gene in the red ICH module