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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Fig. 2

Post-onset anti-HMGB1 2G7 treatment has no effect on disease in SOD1G93A transgenic mice. SOD1G93A mice were intraperitoneally injected weekly with the anti-HMGB1 antibody at 70 days of age (red line). a Left panel shows a Kaplan-Meier plot of ages (in days) in which SOD1G93A mice treated with isotype control (vehicle, 100 μg; orange line) or anti-HMGB1 antibody (100 μg; blue line) reached end-stage of disease (complete hind-limb paralysis and an inability to right itself once placed on its back; n = 12, p = 0.6384, log-rank test). a Right panel shows the end-stage survival age for each litter-matched pair of vehicle- and anti-HMGB1-treated SOD1G93A mice, demonstrating no differences in survival time between the groups. b–d Panels show no difference in body weight (b), motor score (c) and hind-limb grip strength (d) between vehicle (orange line) and anti-HMGB1 (blue line) treated SOD1G93A mice (n = 12, p > 0.05, two-way ANOVA). Data are expressed as mean ± SEM

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