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Table 1 Summary of phenotypic observations used to assign motor scores

From: Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Phenotype

Score 0

Score 1

Score 2

Hind-limb tremor

Normal

Tremor

N/A

Gait abnormalities

Normal

Gait abnormalities

N/A

Hind-limb splay

Normal

Partially collapsed to the lateral midline

Completely collapsed to the lateral midline

Hind-limb paralysis

Normal

Dragging hind-limbs

N/A

Righting reflex

0 s

< 5 s

> 15 s