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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses

Fig. 2

ALX inhibits LPS-induced maturation of BMDC. On day 8 of culture, BMDCs (n = 6) were stimulated with LPS (1 μg/ml) alone or together with ALX at 2 or 10 μM for 48 h. a Flow cytometric analysis of cell surface markers of CD80, CD86, and MHCII in BMDCs. b SEM analysis of BMDCs. The arrows indicate peripheral cellular protrusions. c TEM analysis of BMDCs. The thin arrow indicates well-developed rough endoplasmic reticulum, and the heavy arrow indicates Golgi apparatus. d ELISA analysis of IL-12, IL-23, and IL-6 levels in the supernatants of BMDCs. ※p < 0.05, *p < 0.01, #p < 0.001, NS means no statistical difference

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