Fig. 4

Increased cerebrospinal fluid neurofilament light chain (NF-L) levels in patients who progress to multiple sclerosis. a Levels of intrathecal NF-L and b significant correlation of NF-L levels in multiple sclerosis (MS)-related optic neuritis (ON) patients with cerebrospinal fluid (CSF) sampling delay from symptom onset. Open circles indicate patients that were diagnosed with multiple sclerosis 3 to 12 months after optic neuritis onset. Excluded from analysis are two samples due to few data points in this time interval