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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis

Fig. 4

Therapeutic FTY720 treatment inhibits inflammatory cell (macrophages and IL-17+ cells) infiltration in sciatic nerves of c-EAN rats. a Representative cross sections of sciatic nerves from control and c-EAN rats treated with FTY720 or vehicle (three groups of rats) were labeled with anti-CD68 antibody for macrophage infiltration at 60 dpi. b Representative cross sections of sciatic nerves sampled in the three groups of rats were labeled with anti-IL-17 antibody for IL-17+ cell infiltration at 60 dpi. c Macrophage and d IL-17+ cell numbers per square millimeter at 60 dpi in sciatic nerves from control and c-EAN rats treated with FTY720 or vehicle. Mean values, SEM, and p values are indicated. ****p < 0.001. n, number of rats

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