Fig. 5

Effect of FTY720 on serum IL-17, IFNγ, TNF, IL-4, and IL-10 cytokine. Cytokine levels were evaluated at different stages of the disease (18, 40, and 60 dpi) in the serum collected from control rats that received CFA alone or from c-EAN rats that were treated with FTY720 or vehicle. a IL-17 level was evaluated by ELISA. b–e IFNγ, TNF, IL-4, and IL-10 cytokine levels were measured using cytometric bead array technique. Mean values, SEM, and p values are indicated. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. n, number of rats