Fig. 3

Cx3cr1-Mfp2^−/−mice respond adequately to pro- and anti-inflammatory challenges. a–d Five-month-old (a, b) and 8-month-old (c, d) Cx3cr1-Mfp2^−/− and control mice were challenged with i.p. LPS or vehicle, and the brainstem was analyzed after 6 h for transcript levels of pro-inflammatory markers. n = 4–6 mice/group. e, f Five-month-old Cx3cr1-Mfp2^−/− and control mice were challenged with i.c.v. IL-4 or vehicle, and the frontal cortex contralateral to the injection site was analyzed after 20 h for transcript levels of anti-inflammatory markers. n = 3 mice/group. Cx3cr1-Mfp2^−/− mice compared to control: **p < 0.05, ***p < 0.001. ns, not significant. Error bars indicate SEM