Fig. 5

Microglia in Cx3cr1-Mfp2^−/− brain adopt a normal inflammatory phenotype after nerve injury. Facial nerve was axotomized at the left side (ipsilateral) of the brain, whereas the right facial nerve remained intact in 3-month-old Cx3cr1-Mfp2^−/− and control. Transcript levels of inflammatory and microglial markers were analyzed in facial nuclei at 5 days post-axotomy. The expression of all markers significantly increased at the axotomized ipsilateral side (ipsi) of the brain versus intact contralateral side (contra) in both Cx3cr1-Mfp2^−/− and control mice (significance levels not shown). There were no differences between genotypes at the affected ipsilateral side. Cx3cr1-Mfp2^−/− mice compared to control: *p < 0.05, **p < 0.01, ****p < 0.0001. ns, not significant. n = 5 mice/group. Error bars indicate SEM