Fig. 7

Cx3cr1-Mfp2^−/−mice show a normal clinical phenotype. a, b Normal grip strength in front paws (a) and all paws together (b) in 3-, 5-, and 8-month-old Cx3cr1-Mfp2^−/− mice compared to control mice. c Inverted grid test shows similar performances regarding grip strength and coordination in 8-month-old Cx3cr1-Mfp2^−/− mice and control mice. d, e Eight-month-old Cx3cr1-Mfp2^−/− mice show normal locomotor activity as the number of entries in the corners (d) and total path length (e) in an open field environment is similar to control mice. f, g Eight-months-old Cx3cr1-Mfp2^−/− mice exhibit normal exploratory behavior as the mean distance to the center (f) and number of entries in the center (g) are similar to control mice in an open field environment. h Fear-conditioned memory was assessed by means of the passive avoidance test. Cx3cr1-Mfp2^−/− show a similar delay to traverse to the dark compartment as control mice indicative of a normal cognition. ns, not significant. Error bars indicate SEM. m, months. n = 5–12 mice/group