Fig. 2

Increased numbers of central memory CD8⁺ T lymphocytes with increased pro-inflammatory activation are found in the blood of CRPS participants compared to healthy controls. a A bar graph showing the number of cells in FlowSoM clusters representing the four major CD8⁺ T lymphocyte populations; naive (Tn, CD3⁺CD8⁺CD45RA⁺CCR7⁺), effector (Teff, CD3⁺CD8⁺CD45RA⁺CCR7⁻), effector memory (Tem, CD3⁺CD8⁺CD45RO⁺CCR7⁻), central memory (Tcm, CD3⁺CD8⁺CD45RO⁺CCR7⁺). b Intracellular signalling and functional marker expression levels in the FlowSoM cluster representing central memory CD8⁺ T lymphocytes. All data are presented as group means (± S.E.M.). * represents P < 0.05 in an unpaired Student’s T Test. c Linear correlation between the number of central memory CD8⁺ T and stress scores on DASS21 in the CRPS group. N = 14 CRPS and N = 14 controls. * represents P < 0.05 in a linear regression analysis