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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome

Fig. 2

Increased numbers of central memory CD8+ T lymphocytes with increased pro-inflammatory activation are found in the blood of CRPS participants compared to healthy controls. a A bar graph showing the number of cells in FlowSoM clusters representing the four major CD8+ T lymphocyte populations; naive (Tn, CD3+CD8+CD45RA+CCR7+), effector (Teff, CD3+CD8+CD45RA+CCR7), effector memory (Tem, CD3+CD8+CD45RO+CCR7), central memory (Tcm, CD3+CD8+CD45RO+CCR7+). b Intracellular signalling and functional marker expression levels in the FlowSoM cluster representing central memory CD8+ T lymphocytes. All data are presented as group means (± S.E.M.). * represents P < 0.05 in an unpaired Student’s T Test. c Linear correlation between the number of central memory CD8+ T and stress scores on DASS21 in the CRPS group. N = 14 CRPS and N = 14 controls. * represents P < 0.05 in a linear regression analysis

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