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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome

Fig. 3

Increased numbers of central memory CD4+ T lymphocytes with increased pro-inflammatory activation are found in the blood of CRPS participants compared to healthy controls. a A bar graph showing the number of cells in FlowSoM clusters representing the four major CD4+ T lymphocyte populations; naive (Tn, CD3+CD4+CD45RA+CCR7+), effector (Teff, CD3+CD4+CD45RA+CCR7), effector memory (Tem, CD3+CD4+CD45RO+CCR7), central memory (Tcm, CD3+CD4+CD45RO+CCR7+). b A bar graph showing the number of cells in FlowSoM clusters representing central memory Th1 lymphocytes (CD3+CD4+CD45RO+CCR7+T-bet+) and Tregs (CD3+CD4+CD45RO+CCR7+CD127loCD25+FoxP3+). Intracellular signalling and functional marker expression levels in FlowSoM clusters representing c Th1 lymphocytes and d Tregs. N = 14 CRPS and N = 14 controls. All data are presented as group means (± S.E.M.). * represents P < 0.05 and ** represents P < 0.01 in an unpaired Student’s T Test, and # represents P < 0.01 in a Mann-Whitney U Test

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