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Table 4 Significant increases in major T lymphocyte populations in the blood of CRPS participants. A table showing the numbers of major immune cell populations in the blood of CRPS and healthy controls based on manual gating analysis of mass cytometry output. N = 14 CRPS and N = 14 controls. All data are presented as group means (± S.E.M.). * represents P < 0.05 in unpaired Student’s T test, # represents P < 0.05 in Mann-Whitney U test

From: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome

Cell population Control (cells/ml) ± S.E.M. CRPS (cells/ml) ± S.E.M.
CD3+TCRγδ T cells 446,868 34,128 657,776* 92,487
CD3+TCRγδCD4+ T cells 263,243 20,573 396,510 63,516
CD4+CD45RA+ Naive T cells 103,023 13,699 154,529 26,565
CD4+CD45RO+ Memory T cells 144,787 11,592 208,773 39,029
CD4+CD45RO+T-bet+ Memory Th1 cells 51,318 6575 101,242 23,548
CD4+CD127loCD25+ Tregs 14,782 2127 32,343 9936
CD4+CD127loCD25+CD45RA+ Naive Tregs 4255 909 8190 2653
CD4+CD127loCD25+CD45RO+ Memory Tregs 10,421 1365 23,934 7461
CD4+CD127loCD25+FoxP3+ Tregs 5573 485 11,925* 2736
CD3+TCRαβ + CD8+ T cells 183,550 18,908 261,338 40,889
CD8+CD45RA+ Naive T cells 108,545 16,263 142,125 23,135
CD8+CD45RO+ Memory T cells 74,962 7634 118,769 28,520
CD3+TCRαβ +CD56+ NKT cells 10,092 1296 20,082 7371
CD3+TCRγδ + T cells 8384 1465 15,172 4273
CD19+ B cells 62,633 10,241 93,386 19,075
CD56+CD19CD3 NK cells 64,508 8369 103,364 19,520
HLA-DR+CD19CD3CD56 Myeloid cells 199,230 28,780 260,322 33,995
HLA-DR+CD14+ Classical monocytes 158,330 24,822 207,083 29,342
HLA-DR+CD14+CD16+
Inflammatory monocytes
23,262 2984 28,884 3968
HLA-DR+CD14CD11c+CD1c+CD141 mDC 3101 433 1738# 344
HLA-DR+CD14CD11c+CD141c+CD1c mDC 1030 196 883 119
HLA-DR+CD14CD123+ pDCs 2624 322 2968 727