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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

Fig. 5

UA decreased glial reactivity in APP/PS1 mice. a Representative immunostaining of Iba-1 in the cerebral cortex and hippocampus of the different groups. Scale bar = 200 μm. b Quantification of microglia number in the cortex and hippocampus. c Colocalization of fluorescent GFAP (green) and DAPI (blue) in the hippocampus and cortex. Scale bar = 200 μm. d Quantification of astrocyte number in the cerebral cortex and hippocampus. e Colocalization of fluorescent Aβ (green), Iba1 (red), and DAPI (blue) in the cerebral cortex and hippocampus. Scale bar = 50 μm. f Colocalization of fluorescent Aβ (red), GFAP (green), and DAPI (blue) in the cerebral cortex and hippocampus. Scale bar = 50 μm. All of the quantified data are presented as the mean ± SEM, n = 8–10/group, three sections per animal, **P < 0.01. WT wild-type, UA urolithin A

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