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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Fig. 5

IL-10 modulates the STAT-3 pathway to suppress NLRP-3 expression by microglia. a–c Microglia from epileptic-seizure mice, STAT-1 siRNA mice, or STAT-3 siRNA mice were incubated for 8 h with LPS. NLRP-3 levels in cell lysates were measured by Western blots (n = 6). Data represent mean ± SEM of four individual experiments. **P < 0.01; ns not significant

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Journal of Neuroinflammation

ISSN: 1742-2094