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Table 1 Effect of PTX on seizure in mice

From: Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Dose of PTX (mg/kg, i.p.) Number of mice tested Mice with status epilepticus Mice surviving status epilepticus Seizure score ≥ 3 Total mortality
Saline control 6 0 0 0 0
0.25 6 0 0 0 0
0.5 6 0 0 0 0
1 6 2 (33.3%)* 1 (50%) 1 (16.7%) 1 (16.7%)
2 6 5 (83.3%)** 4 (80%) 4 (66.7%) 1 (16.7%)
  1. Effects of PTX on status epilepticus mice. (n = 6 in each group; *P < 0.05 and **P < 0.01 compare the PTX-treated with the saline control group for the corresponding parameters)
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Journal of Neuroinflammation

ISSN: 1742-2094