|
Dose of PTX (mg/kg, i.p.)
|
Seizure score (mean ± SEM)
|
Number of + ve responder/total (% of + ve responders)
|
Time to onset of status epilepticus (min) (mean ± SEM)
|
Mice surviving status epilepticus
|
Total mortality
|
Mice developing spontaneous seizures aster epilepticus
|
|---|
|
Saline control
|
0
|
0/30 (0)
|
60 ± 0
|
30
|
0
|
0
|
|
2
|
4.5 ± 1.0
|
48/50 (96%)**
|
3.3 ± 1.0
|
42 (87.5%)
|
8 (16%)
|
41 (97.6)
|
- The effect of PTX on the frequency of epilepsy with spontaneous recurrent seizures developing in mice was evaluated. (n = 30 in the saline control group and n = 50 in the PTX-treated group; **P < 0.01 compares the PTX-treated and the saline control groups for the corresponding parameters)
