Skip to main content

Table 2 Results from the study of this investigation on PTX (2 mg/kg) in mice

From: Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Dose of PTX (mg/kg, i.p.)

Seizure score (mean ± SEM)

Number of + ve responder/total (% of + ve responders)

Time to onset of status epilepticus (min) (mean ± SEM)

Mice surviving status epilepticus

Total mortality

Mice developing spontaneous seizures aster epilepticus

Saline control

0

0/30 (0)

60 ± 0

30

0

0

2

4.5 ± 1.0

48/50 (96%)**

3.3 ± 1.0

42 (87.5%)

8 (16%)

41 (97.6)

  1. The effect of PTX on the frequency of epilepsy with spontaneous recurrent seizures developing in mice was evaluated. (n = 30 in the saline control group and n = 50 in the PTX-treated group; **P < 0.01 compares the PTX-treated and the saline control groups for the corresponding parameters)