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Table 2 Results from the study of this investigation on PTX (2 mg/kg) in mice

From: Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Dose of PTX (mg/kg, i.p.) Seizure score (mean ± SEM) Number of + ve responder/total (% of + ve responders) Time to onset of status epilepticus (min) (mean ± SEM) Mice surviving status epilepticus Total mortality Mice developing spontaneous seizures aster epilepticus
Saline control 0 0/30 (0) 60 ± 0 30 0 0
2 4.5 ± 1.0 48/50 (96%)** 3.3 ± 1.0 42 (87.5%) 8 (16%) 41 (97.6)
  1. The effect of PTX on the frequency of epilepsy with spontaneous recurrent seizures developing in mice was evaluated. (n = 30 in the saline control group and n = 50 in the PTX-treated group; **P < 0.01 compares the PTX-treated and the saline control groups for the corresponding parameters)