Dose of PTX (mg/kg, i.p.) | Seizure score (mean ± SEM) | Number of + ve responder/total (% of + ve responders) | Time to onset of status epilepticus (min) (mean ± SEM) | Mice surviving status epilepticus | Total mortality | Mice developing spontaneous seizures aster epilepticus |
---|---|---|---|---|---|---|
Saline control | 0 | 0/30 (0) | 60 ± 0 | 30 | 0 | 0 |
2 | 4.5 ± 1.0 | 48/50 (96%)** | 3.3 ± 1.0 | 42 (87.5%) | 8 (16%) | 41 (97.6) |