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Table 3 Association between blood cell counts derived ratios, and risk of all-cause dementia and dementia subtypes

From: Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

Laboratory assessment#

All-cause dementia, censored for stroke (n/N = 579/8008)

Alzheimer’s disease (n/N = 543/8313)

Vascular dementia (n/N = 31/8313)

 

HR (95% CI)

HR (95% CI)

HR (95% CI)

Granulocytes

1.13 (0.83–1.56)

1.03 (0.75–1.42)

1.99 (0.52–7.55)

 Corrected for platelets and lymphocytes

1.36 (0.96–1.93)

1.12 (0.79–1.58)

1.92 (0.44–8.41)

Platelets

1.45 (1.07–1.96)*

1.59 (1.17–2.17)*

3.86 (1.02–14.6)*

 Corrected for granulocytes and lymphocytes

1.47 (1.07–2.02)*

1.63 (1.18–2.27)*

3.39 (0.84–13.7)

Lymphocytes

0.80 (0.62–1.02)

0.85 (0.66–1.10)

0.76 (0.25–2.30)

 Corrected for granulocytes and platelets

0.76 (0.58–0.98)*

0.81 (0.62–1.06)

0.64 (0.20–2.03)

Granulocyte-to-lymphocyte ratio

1.33 (1.07–1.65)*

1.17 (0.95–1.46)

1.85 (0.74–4.62)

Platelet-to-lymphocyte ratio

1.31 (1.07–1.60)*

1.30 (1.06–1.60)*

1.99 (0.82–4.81)

Systemic immune-inflammation index

1.19 (1.01–1.41)*

1.15 (0.97–1.37)

1.77 (0.87–3.63)

  1. Abbreviations: CI confidence interval, HR hazard ratio, n number of incident dementia events, N number of participants for analysis. Models are adjusted for age, sex, education, smoking status, body mass index, diabetes mellitus, history of stroke, and APOE4 ε4 carrier status
  2. #All types of blood cells and their derived ratios were natural logarithmic transformed
  3. Number of participants for analysis is 8313 minus participants with a history of stroke (n = 305)
  4. *Indicates statistically significant result