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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Fig. 2

TGFβ1 contributes to HE-induced neurological decline. a Neurological score analyses as assessed by reflex scores and ataxia at the indicated hours post-AOM injection in AOM-treated mice pre-treated with IgG1 or anti-TGFβ1. b Time taken to progress to coma in hours of AOM-treated mice infused with IgG1 or anti-TGFβ1. c Representative H&E images from the livers of vehicle- or AOM-treated mice pre-treated with IgG1 or anti-TGFβ1. d Serum ALT levels of vehicle- or AOM-treated mice pre-treated with IgG1 or anti-TGFβ1. e Serum AST levels of vehicle- or AOM-treated mice pre-treated with IgG1 or anti-TGFβ1. *p < 0.05 compared to vehicle and IgG1-treated mice, #p < 0.05 compared to AOM- and IgG1-treated mice. For all analyses, n = 4 for AOM-treated with IgG1 groups and n = 5 for AOM and anti-TGFβ1 groups.

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Journal of Neuroinflammation

ISSN: 1742-2094