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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Fig. 4

Neuronal TGFβR2 mediates AOM-induced neurological decline. a Neurological score analyses as assessed by reflex scores and ataxia at the indicated hours post-AOM injection in TGFβR2wt/wt and TGFβR2ΔNeu mice. b Time taken to progress to coma in TGFβR2wt/wt and TGFβR2ΔNeu mice administered AOM. c Representative H&E images from the livers of TGFβR2wt/wt and TGFβR2ΔNeu mice administered vehicle or AOM. d Serum ALT levels of TGFβR2wt/wt and TGFβR2ΔNeu mice administered vehicle or AOM. e Serum AST levels of TGFβR2wt/wt and TGFβR2ΔNeu mice administered vehicle or AOM. *p < 0.05 compared to TGFβR2wt/wt vehicle-treated mice, #p < 0.05 compared to TGFβR2wt/wt AOM-treated mice. n = 4 for all analyses

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