Fig. 5

Neuroinflammation during AOM-induced HE is driven by TGFβR2 in neurons. a Representative staining and quantification for IBA1 (red) in the cortex from of TGFβR2^wt/wt and TGFβR2^ΔNeu mice administered vehicle or AOM. DAPI (blue) was used to stain nuclei. Scale bar indicates 75 μM. b CCL2 protein expression normalized by total protein concentration in the cortex of TGFβR2^wt/wt and TGFβR2^ΔNeu mice administered vehicle or AOM. c CX3CL1 protein expression normalized by total protein concentration in the cortex of TGFβR2^wt/wt and TGFβR2^ΔNeu mice administered vehicle or AOM. d IL-1β protein expression normalized by total protein concentration in the cortex of TGFβR2^wt/wt and TGFβR2^ΔNeu mice administered vehicle or AOM. e TNFα protein expression normalized by total protein concentration in the cortex of TGFβR2^wt/wt and TGFβR2^ΔNeu mice administered vehicle or AOM. *p < 0.05 compared to TGFβR2^wt/wt vehicle-treated mice, ^#p < 0.05 compared to TGFβR2^wt/wt AOM-treated mice. n = 3 for all analyses