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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Fig. 8

TGFβ1-induced CCL2 and CX3CL1 modulation in neurons promote microglia activation. a Relative IL-1β and (b) TNFα mRNA expression in EOC-20 cells treated with C021, INCB, or recombinant CX3CL1 following supplementation with conditioned media from HT-22 cells treated with recombinant TGFβ1. c Phagocytosis activity, reported as fluorescence intensity of phagocytized E. coli bioparticles, in EOC-20 cells treated with C021, INCB, or recombinant CX3CL1 following supplementation with conditioned media from HT-22 cells treated with recombinant TGFβ1. *p < 0.05 compared to EOC-20 supplemented with basal HT-22 conditioned media. #p < 0.05 compared to EOC-20 supplemented with TGFβ1-treated HT-22 conditioned media. n = 3 for mRNA analyses and n = 7 for phagocytosis activity assay

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Journal of Neuroinflammation

ISSN: 1742-2094