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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

Fig. 7

Chronic treatment with IL-1ra (IL-1β antagonist) attenuated increased expression levels of c-Fos, p-ERK and CGRP, but not effect on NLRP3. a Nitroglycerin (NTG) induced increase of NLRP3 protein expression. But NLRP3 expression had no significant differences between the daily IL-1ra preventative treatment group and NTG group. bd The expression of p-ERK (b), CGRP (c) and c-Fos (d) showed upregulation in the NTG group compared to those in the saline group; compared with NTG, daily IL-1ra preventative treatment decreased these protein levels. There were no significant differences between the NTG and NTG+PBS groups. Statistical analyses were performed by one-way ANOVA, followed by a Tukey test; ***p < 0.001 vs. the saline group, ###p < 0.001 vs. the NTG group (n = 6 mice per group)

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