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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

Fig. 9

The NLRP3 pathway is a key regulator of the sensitization of a chronic migraine. Nitroglycerin (NTG) produces acute and chronic migraine-associated pain. In contrast, the NLRP3 inhibitor MCC950 blocks NTG-induced hyperalgesia. Blocking downstream IL-1β has a similar effect. These results indicate that NTG-associated pain is critically mediated by the NLRP3/IL-1β pathway. Our work indicates that inhibitors or negative modulators of the NLRP3/IL-1β pathway could be effective migraine treatments

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Journal of Neuroinflammation

ISSN: 1742-2094