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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?

Fig. 8

Abridged general view. Diabetes upregulated the expression of caveolin-1 and the glycosylation of CD147 in both astrocytes and endothelium and further elevated the activities of MMPs, especially MMP-2/9. Higher MMP activity accelerates the degradation of BBB components and ultimately leads to erythrocyte leakage after rt-PA treatment of acute cerebral ischemia

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Journal of Neuroinflammation

ISSN: 1742-2094