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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model

Fig. 4

Summary of results of nerve conduction studies (NCS). Sciatic motor NCS were performed by stimulating above the ankle (distal site) or at the sciatic notch (proximal site) and recording from the sole (a). Stimulation sites are marked by arrows, the recording site by the asterisk. Almost equal CMAP amplitudes were measured in controls (b), conduction blocks defined as a ratio of the distal to proximal CMAP of > 1.5 were found in patient animals (c). The ratio of distal to proximal CMAP was increased in animals injected with IgG of the acute patients compared to controls (d). F waves following the CMAP were measured in controls (e), whereas loss of F waves was found in patient animals (f). F wave persistence was mostly normal (70–100%, black) in animals injected with IgG of the low titre patient and controls, whereas complete loss of F waves (white) was found in the majority of animals injected with IgG of the acute patient and many animals injected with IgG of the chronic patient (g)

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