Fig. 7
From: Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model
Confocal microscopy image of paranodes and box plots illustrating morphometric data and complement deposition of the acute patient. Paranodal immunofluorescence staining with anti-Caspr is reduced at paranodes of rats injected with IgG of the acute patient (a, lower image) compared to paranodes of a control rat (a, upper image). Scale bar = 10 μm. Complement deposition at the paranodes can be detected by immunofluorescence staining with anti-C1q (b). Morphometric analysis revealed a reduction of sum intensity (c), length of the nodal complex (d) and paranodal volume (e) in rats injected with IgG of the acute patient compared to control rats. (*0.1 > p > 0.01, **0.01 > p > 0.001, ***0.001 > p)